Matthew Karpenko, MS, D.O.

Matthew Karpenko, MS, D.O.
Board-Certified in Hematology and Medical Oncology
Specialty Training: 
M.S., Human Genetics Roswell Park Cancer Institute, Buffalo, NY
Medical School: 
Lake Erie College of Osteopathic Medicine


My decision to become a physician began in junior high school with a strong desire to help people. I received my undergraduate degree in biology at Syracuse University in 1996.

During my time at Syracuse, I was diagnosed with malignant melanoma which required surgery and possible chemotherapy. It recurred again requiring more surgery. From that point on studying cancer became personal. I wanted to understand the mechanism by which cancer occurs and dedicated myself to further study at Roswell Park’s Human working on the Human Genome Project looking for tumor suppressor genes in colon, breast, and Wilms’ tumors.

I enrolled at Lake Erie College of Osteopathic Medicine knowing full well that studying Hematology/Oncology was my dream. Throughout medical school I was a patient care technician in the ICU to take care of patients. I understood the importance of working together as a team to provide the best clinical outcomes.

I completed my residency in Internal Medicine at SUNY Upstate Wilson Memorial Regional Medical Center in Johnson City, NY. At the end of my intern year, I applied and was accepted at The Ohio State University Medical Center James Cancer Hospital cancer fellowship. It was here that I received outstanding mentorship and was given the amazing opportunities of: interning at the FDA and the NIH’s (Cancer Therapeutics Evaluation Program), and writing grants to fund my own basic science research project to be Principal Investigator of my own Phase I Clinical Trial in malignant mesothelioma which I presented at ASCO in 2008.

I have practiced in Florida, South Carolina and North Carolina. After the birth of my sons Nicholas, and Michael, my wife and I knew we wanted to raise our children in Upstate, New York and moved home to Jamesville, NY in 2016. Prior to joining HOA, I served as Chief of Medical Oncology and Hematology at Guthrie Cortland Medical Center and served as Associate Medical Director for Hospicare of Thompkins County in Ithaca, NY. This experience taught me compassion, humbleness, honor and how privileged it is to take care of those diagnosed with a terminal illness. My philosophy has always been to care for my patients like they are family and it reminded me of how challenging but rewarding the field can be.

I chose HOA of CNY as I knew from the moment I walked in, it is a very special place to treat patients. HOA is unlike any other practice I’ve worked at. They treat patients as family and are very dedicated to working together as a team to give exemplary care.

When I am not practicing medicine, I enjoy spending time with my family and being outside whether it is chasing my boys, or flying a kite with them, or building massive snow forts. We definitely enjoy the snow. I love going to the gym to weight train and running half marathons to relieve stress. Our family is very active parishioners at Immaculate Conception Church. Most of all, my wife and I are extremely grateful to the community we live and for the opportunity to raise our children where we grew up while being close to all our family right here in beautiful Upstate NY!